N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide KOBE0065

Name	N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide
Synonyms	Kobe0065 Kobe 0065 Kobe-0065 Kobe0065, 436133-68-5 N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE N-(3-Chloro-4-Methylphenyl)-2-[2,6-dinitro-4-(trifluoroMethyl)phenyl]-hydrazinecarbothioaMide N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide Kobe-0065 N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide KOBE0065
CAS	436133-68-5

Molecular Formula	C15H11ClF3N5O4S
Molar Mass	449.79
Melting Point	>166°C (dec.)
Solubility	DMSO: soluble15mg/mL, clear
Appearance	powder
Color	white to beige
Storage Condition	Keep in dark place,Sealed in dry,2-8°C
In vitro study	The compounds of the Kobe0065 family bind to Ras-GTP and have anti-proliferative activity against cancer cells carrying an activated ras oncogene. It effectively inhibits the interaction of Ras ~ GTP with its effector proteins such as Raf, PI3K, RalGDS and the regulator/effector Sos, with a broad binding specificity for various small GTPases of the Ras family.
In vivo study	Kobe0065 has anti-tumor activity. Tumors treated with this compound significantly increased their apoptotic cells without significant weight loss.

Last Update：2024-01-02 23:10:35

biological activity	Kobe0065 is an inhibitor of H-Ras-cRaf1 interaction and can effectively inhibit the combination of H-Ras · GTP and c-Raf-1 RBD with a Ki value of 46±13 μM.
target	TargetValue H-Ras-cRaf1 interaction ()
Target	Value
in vitro study	Kobe0065 family compounds bind to Rasevents and have anti-proliferative activity against cancer cells carrying the ras-activated oncogene. It effectively inhibits the interaction of RasaS GTP with its effector proteins such as Raf, PI3K, RalGDS and regulatory/effector Sos, and has a wide range of binding specificity for small GTP enzymes of various Ras families.
in vivo research	Kobe0065 have anti-tumor activity. Tumors treated with this compound significantly increased their apoptotic cells without significant weight loss.

Last Update：2024-04-10 22:29:15

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CAS: 436133-68-5
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Product Name: KOBE-0065 Request for quotation
CAS: 436133-68-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Wechat: 18301782025

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N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide KOBE0065 Request for Quotation